In late 2012, this cat named Tarder Sauce rose to fame for her adorable grumpy face. Nicknamed Grumpy Cat, this cat was a very popular meme with many pessimistic and humorous captions.
Alex Christopher LaBeouf, also known as Alex from Target was recognized all over Twitter for his good looks when a customer took a photo of him and posted it. In November of 2014, #AlexFromTarget trended and had around 1 million retweets in only 24 hours.
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The History of Memes 